In a world where everyone's trying to get healthier, finding effective ways to lose weight is a big deal. People are always looking for ways to make the journey a bit easier. One (re)emerging area is weight loss drugs – new medications include weekly injections that could help you to shed those extra pounds. These medications were initially developed to treat diabetes. Their use was expanded to help achieve meaningful weight loss for patients struggling with obesity. Along the way studies have shown them effective in reducing the risk of cardiac complications in diabetes. Now new research suggests weight loss drugs offer protection from heart disease.
The results of the SELECT (Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity) trial were published in New England Journal of Medicine - December 14, 2023. This is the first trial that studied cardiac outcomes from long term use of GLP1 inhibitors (semaglutide) in patients without diabetes. The study enrolled over 17000 patients age greater than 45 who were overweight (BMI > 27) and had pre-existing heart disease. It was a double-blind, randomized, placebo-controlled study, the highest quality study type in medical research. They followed patients for ~3 years. The most impressive outcomes includes reduction the incidence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke.
Embarking on a weight loss journey is a personal choice that should prioritize both physical and mental well-being. While shedding excess pounds can lead to improved health outcomes, it's essential to approach the process with a mindset that embraces body acceptance. However, it's heartening to know that after decades of stagnation - there are tools to help patient achieve their weight loss goals. And unlike medications of the past - more and more studies are showing important collateral improvements to overall health.
If you are interested in discussing if these medications may be right for you - reach out to your primary care provider. If you are seeking a thoughtful healthcare provider, building an innovative care model - please fill out our contact form to connect with Katie Mordino ANP-BC to schedule a house call.
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